HHS grants
The Department of Health and Human Services is the largest federal grant maker. Its agencies, including NIH, HRSA, CDC, SAMHSA and the Administration for Children and Families, fund health, research, child care, Head Start and social services.
- Open now
- 414
- Upcoming
- 340
- Next deadline
- October 22, 2026
Open and forecast HHS opportunities
From Grants.gov, soonest deadline first.
- Closes22 OCT
Optimizing Behavioral Sleep Interventions for Adolescents and Young Adults (R34 Clinical Trial Required)
NIH · Nonprofits, Tribes, School districts, +12 more
NIMH seeks applications for pilot research to adapt, optimize, and test behavioral interventions that address common sleep problems in adolescents and young adults with or at risk for a mental health disorder. This notice of funding opportunity (NOFO) supports pilot clinical trials designed to evaluate the feasibility, tolerability, acceptability, safety, an
- Closes26 OCT
Long-term health outcomes of people living with spina bifida
CDC · Counties, Private colleges, Cities and towns, +9 more
The purpose of component A (8-11 awardees) of this NOFO is to collect high-quality longitudinal data on children and adults with spina bifida (SB) who receive care in specialized spina bifida clinics participating in the National Spina Bifida Patient Registry (NSBPR). The purpose of component B (6-8 awardees) is to implement and evaluate the Urologic Managem
- Closes30 OCT
GREGoRi Data Coordination and Outreach Center (U01, Clinical Trials Not Allowed)
NIH · School districts, Tribal organizations, Nonprofits, +12 more
The Genomics Research to Elucidate the Genetics of Rare Diseases:innovation (GREGoRi) initiative seeks to accelerate a paradigm shift in rare disease diagnosis by reimagining the tools, molecular technologies and analytical approaches used to identify the causal gene(s) and/or variant(s) underlying rare genetic disorders. The purpose of this Notice of Fundin
- Closes30 OCT
GREGoRi Innovation Projects (U01 Clinical Trial Optional)
NIH · Special districts, Public colleges, Tribal organizations, +12 more
The Genomics Research to Elucidate the Genetics of Rare Diseases:innovation (GREGoRi) initiative seeks to accelerate a paradigm shift in rare disease diagnosis by reimagining the tools, molecular technologies and analytical approaches used to identify the causal gene(s) and/or variant(s) underlying rare genetic disorders. This Notice of Funding Opportunity i
- Closes30 OCT
GREGoRi Technology Integration Center (U01, Clinical Trials Optional)
NIH · Housing authorities, For-profits, School districts, +12 more
The Genomics Research to Elucidate the Genetics of Rare Diseases:innovation (GREGoRi) initiative seeks to accelerate a paradigm shift in rare disease diagnosis by reimagining the tools, molecular technologies and analytical approaches used to identify the causal gene(s) and/or variant(s) underlying rare genetic disorders. The purpose of this Notice of Fundin
- Closes30 OCT
HEAL Initiative: Whole Joint Health Program (R61/R33 Clinical Trial Required)
NIH · Public colleges, Tribal organizations, Tribes, +12 more
The NIH Helping to End Addiction Long-term ® (HEAL) Initiative is releasing this Notice of Funding Opportunity (NOFO) to support a phased mechanistic clinical research program focusing on understudied biological mechanisms that drive joint pain. The phased projects supported by this program (of up to five years total in duration) will first identify and vali
- Closes02 NOV
Clinical Observational (CO) Studies in Musculoskeletal, Rheumatic, and Skin Diseases (R01 Clinical Trial Not Allowed)
NIH · States, Public colleges, Private colleges, +12 more
This Clinical Observational (CO) Studies in Musculoskeletal, Rheumatic, and Skin Diseases (R01 Clinical Trial Not Allowed) PAR, was re-issued as a result of the Simplifying Review of Research Project Grant Applications [link: https://grants.nih.gov/policy-and-compliance/policy-topics/peer-review/simplifying-review]. The Simplified Review changes in Section V
- Closes02 NOV
Exploratory Clinical Trial Grants in Arthritis and Musculoskeletal and Skin Diseases (R61 Clinical Trial Required)
NIH · Public colleges, States, Special districts, +12 more
This Exploratory Clinical Trial Grants in Arthritis and Musculoskeletal and Skin Diseases (R61 Clinical Trial Required) PAR, a re-issue of PAR-24-035, was re-issued as a result of the Simplifying Review of Research Project Grant Applications [link: https://grants.nih.gov/policy-and-compliance/policy-topics/peer-review/simplifying-review]. The Simplify Review
- Closes02 NOV
National Indian Health Outreach and Education
HHS · Tribal organizations, Nonprofits, Tribes, Others
The purpose of this NOFO is to further the IHS mission and goals related to providing quality health care to the AI/AN community through outreach and education. Our focus is on promoting awareness, visibility, training, technical assistance, and education in the following components:Health education and outreach.Rural Health Transformation review and outreac
- Closes05 NOV
Developing novel theory and methods for understanding the genetic architecture of complex human traits (R01 Clinical Trial Not Allowed)
NIH · States, Nonprofits, Counties, +12 more
The goal of this NOFO is to support applications for novel theory and methods development that enable better understanding of how genetic and non-genetic factors contribute to complex trait variation across individuals, families, and populations. Approaches should be interdisciplinary drawing from the natural and social sciences, account for interdependencie
- Closes05 NOV
Emerging Infections Network - Research for Preventing, Detecting, and Managing Travel-associated Infectious Diseases
CDC · Counties, Cities and towns, Nonprofits (not 501(c)(3)), +10 more
The focus of this notice of funding opportunity (NOFO) is to produce insights into disease detection and prevention strategies, burden, severity, diagnostics, treatment, and outcomes of infectious diseases in international travelers. Timely surveillance and sentinel detection are essential for collecting actionable data. The research should:Address public he
- Closes05 NOV
US Travelers Health Research, Surveillance, Communication, and Outreach Network
CDC · States, Tribal organizations, Public colleges, +10 more
The NOFO supports CDC"s efforts to protect U.S. residents traveling internationally. The goal is to help U.S. travelers with pre-travel preparation, access to timely health information while traveling, and timely research on health conditions.The project will:Improve access to high quality travel preparation information for both healthcare providers and trav
- Closes06 NOV
Limited Competition for the Continuation of the Caring for OutPatiEnts after Acute Kidney Injury (COPE-AKI) Clinical Centers (U01 Clinical Trial Required)
NIH · Others
This is a Notice of Funding Opportunity (NOFO) for a Limited Competition that will invite application(s) from eligible organization(s) to apply. Please see Section III. Eligibility for additional information. In accordance with NIH standard peer-review processes, the application(s) will be peer-reviewed, and only meritorious application(s) will be considered
- Closes06 NOV
Secondary Analysis and Integration of Existing Data to Elucidate Cancer Risk and Related Outcomes (R01 Clinical Trial Not Allowed)
NIH · Nonprofits (not 501(c)(3)), Private colleges, Tribal organizations, +12 more
Through this Notice of Funding Opportunity (NOFO), the National Cancer Institute (NCI) along with other participating Institutes encourages submission of applications proposing to conduct secondary data analysis and integration of existing datasets and database resources, with the ultimate aim to elucidate cancer risk and related outcomes (e.g., risk predict
- Closes09 NOV
Single Source for the Continuation of the Caring for OutPatiEnts after Acute Kidney Injury (COPE-AKI) Scientific and Data Research Center (U01 Clinical Trial Required)
NIH · Others
Applications for a 3-year extension/renewal of the Caring for OutPatiEnts after Acute Kidney Injury (COPE-AKI) clinical trial consortium are requested to fully meet the enrollment targets, complete participant follow-up, and finalize data analysis and dissemination of study findings. This Notice of Funding Opportunity (NOFO) invites a Single Source applicati
- Closes09 NOV
Single Source for the Continuation of the Epidemiology of Diabetes Interventions and Complications (EDIC) Study Research Center (Collaborative U01 Clinical Trial Not Allowed)
NIH · Others
This is a Notice of Funding Opportunity (NOFO) for a Single Source that will invite an application from the eligible organization to apply. Please see Section III. Eligibility for additional information. In accordance with NIH standard peer-review processes, applications will be peer-reviewed, and only meritorious applications will be considered for funding.
- Closes10 NOV
Advanced Development and Validation of Emerging Technologies for Basic and Clinical Cancer Research (R33 Clinical Trial Not Allowed)
NIH · Tribes, School districts, Cities and towns, +12 more
Through this Notice of Funding Opportunity (NOFO), the National Cancer Institute (NCI) invites grant applications proposing exploratory research projects focused on further development and technical validation of emerging technologies offering novel capabilities for the molecular or cellular characterization of cancer or for improved handling and quality con
- Closes10 NOV
Amyotrophic Lateral Sclerosis (ALS) Intermediate Patient Population Expanded Access (U01 Clinical Trial Required)
NIH · School districts, Others, Tribes, +12 more
The purpose of this Notice of Funding Opportunity (NOFO) is to solicit applications for the conduct of scientific research utilizing data from expanded access (EA) for investigational drugs or biological products as described in section 561 of the Federal Food, Drug, and Cosmetic Act (21 U.S.C. 360bbb). These applications will target intermediate size popula
- Closes10 NOV
Clinical Research Network on Antimicrobial Resistance (UM1 Clinical Trial Required)
NIH · For-profits, Cities and towns, Housing authorities, +12 more
The purpose of this notice of funding opportunity (NOFO) is to support a Clinical Research Network (CRN) on Antimicrobial Resistance (AMR). The program aims to design, implement, and manage clinical research that addresses pivotal clinical questions related to AMR through a coordinated and integrated CRN. The CRN will comprise four centers: the Scientific Le
- Closes10 NOV
Data Coordinating Center for the Aging and Alzheimer’s Disease Mouse Brain Atlas (AD-MBA) (U24 Clinical Trial Not Allowed)
NIH · Tribal organizations, Others, Private colleges, +12 more
This Notice of Funding Opportunity (NOFO) invites applications proposing a Data Coordinating Center that integrates and disseminates multiscale mouse brain datasets for the aging and Alzheimer's disease (AD) research community. The Data Coordinating Center will establish the Aging and AD Mouse Brain Atlas (AD-MBA), which will serve as a central, unified rese
- Closes10 NOV
Early-Stage Innovative Technology Development for Basic and Clinical Cancer Research (R61 Clinical Trial Not Allowed)
NIH · Counties, States, School districts, +12 more
Through this Notice of Funding Opportunity (NOFO), the National Cancer Institute (NCI) solicits grant applications proposing to develop innovative technologies offering new capabilities for the molecular or cellular characterization of cancer or for improved handling and quality control of biospecimens for basic, clinical, or epidemiological cancer research.
- Closes10 NOV
Infectious Diseases Clinical Trials Network (IDCTN) (UM1 Clinical Trial Required)
NIH · Cities and towns, Others, Housing authorities, +12 more
The purpose of this notice of funding opportunity (NOFO) is to solicit applications for an Infectious Diseases Clinical Trials Network (IDCTN). The IDCTN, comprised of the Clinical Trial Evaluation Units (CTEUs) and a Network Coordination Center (NCC), supports the evaluation of interventions for emerging and chronic infections. The CTEUs design and implemen
- Closes10 NOV
Limited Competition: NIH Research Evaluation and Commercialization Hubs (REACH) (SB0 Clinical Trial Optional)
NIH · Nonprofits (not 501(c)(3)), Private colleges, Public colleges, Nonprofits
This Notice of Funding Opportunity (NOFO) announces the renewal of the NIH Research Evaluation and Commercialization Hub (REACH) program, established to facilitate and accelerate the translation of academic biomedical discoveries into products that improve patient care and public health. Through this program, NIH will provide the qualifying institutions with
- Closes10 NOV
Pilot Projects to Enhance the Human Virome Program (R03 Clinical Trials Not Allowed)
NIH · Tribal organizations, Cities and towns, Others, +12 more
The Common Fund Human Virome Program (HVP) aims to extensively and comprehensively characterize the "healthy" human virome (the collection of viruses that normally reside inside the human body without evidence of disease) and create tools, models, and methods that will enable an in-depth study of its variation and composition in relation to host factors and
- Closes13 NOV
NCCIH Natural Product Early Phase Clinical Trial Award (R33 Clinical Trial Required)
NIH · Cities and towns, Tribes, For-profits, +12 more
This Notice of Funding Opportunity (NOFO) encourages applications for investigator-initiated, early phase, clinical trials of natural products (i.e., botanicals, dietary supplements, and probiotics), which have a strong scientific premise to justify further clinical testing. For this NOFO, natural products include promising nutritional regimens that standard
Showing 25 of 754, soonest first. The grant finder lists the rest.
Where HHS grant money went in 2025
Awards from October 2024 to September 2025, from USAspending.gov.
| Program (Assistance Listing) | Awarded |
|---|---|
| Grants to States for Medicaid 93.778 | $666 billion |
| Children's Health Insurance Program 93.767 | $21 billion |
| Temporary Assistance for Needy Families 93.558 | $17 billion |
| 1332 State Innovation Waivers 93.423 | $16 billion |
| Head Start 93.600 | $12 billion |
| Child Care and Development Block Grant 93.575 | $8.6 billion |
| Health Center Program 93.224 | $5.3 billion |
| Child Support Enforcement 93.563 | $4.6 billion |
| Recipient | Awarded |
|---|---|
| Southwest Key Programs INC | $672 million |
| The General Hospital Corporation | $612 million |
| Compass Connections | $508 million |
| Brigham & Womens Hospital INC | $395 million |
| Vanderbilt University Medical Center | $375 million |
| Fred Hutchinson Cancer Center | $352 million |
| The Mental Health Association of New York City, INC. | $283 million |
| Catholic Charities Diocese of Fort Worth Endowment, INC. | $273 million |
Questions
When is the next HHS grant deadline?
The next deadline is October 22, 2026 for Optimizing Behavioral Sleep Interventions for Adolescents and Young Adults (R34 Clinical Trial Required).
How do I apply for an HHS grant?
Register your organization in SAM.gov to get a Unique Entity ID, create a Grants.gov account, then find the opportunity and submit before its deadline. Some agencies finish the application in their own system, such as JustGrants, eRA Commons or Research.gov.
Can individuals get HHS grants?
Rarely. Federal grants go mostly to organizations: nonprofits, local governments, tribes, schools, colleges and, in research programs, small businesses. Help for individuals usually comes through state and local agencies.
Do I have to pay to apply for a grant?
No. Real grant programs never charge to apply or to receive an award. Anyone asking for a fee before you get grant money is running a scam.